| Tuesday 18 September 2007 | |||
| Marseille | 2-0 | Besiktas | 19:45 |
| Porto | 1-1 | Liverpool | 19:45 |
| Chelsea | 1-1 | Rosenborg | 19:45 |
| Schalke | 0-1 | Valencia | 19:45 |
| Real Madrid | 2-1 | Bremen | 19:45 |
| Olympiakos | 1-1 | Lazio | 19:45 |
| Milan | 2-1 | Benfica | 19:45 |
| Shakhtar | 2-0 | Celtic | 19:45 |
| Wednesday 19 September 2007 | |||
| Rangers | 2-1 | Stuttgart | 19:45 |
| Barcelona | 3-0 | Lyon | 19:45 |
| Roma | 2-0 | Dynamo Kyiv | 19:45 |
| Sporting | 0-1 | Manchester United | 19:45 |
| PSV | 2-1 | CSKA Moscow | 19:45 |
| Fenerbahce | 1-0 | Inter | 19:45 |
| Arsenal | 3-0 | Sevilla | 19:45 |
| Slavia Prague | 2-1 | Steaua Bucharest | 19:45 |
| Tuesday 2 October 2007 | |||
| Lyon | 0-3 | Rangers | 19:45 |
| Stuttgart | 0-2 | Barcelona | 19:45 |
| Manchester United | 1-0 | Roma | 19:45 |
| Dynamo Kyiv | 1-2 | Sporting | 19:45 |
| Inter | 2-0 | PSV | 19:45 |
| CSKA Moscow | 2-2 | Fenerbahce | 18:30 |
| Steaua Bucharest | 0-1 | Arsenal | 19:45 |
| Sevilla | 4-2 | Slavia Prague | 19:45 |
| Wednesday 3 October 2007 | |||
| Liverpool | 0-1 | Marseille | 19:45 |
| Besiktas | 0-1 | Porto | 19:45 |
| Valencia | 1-2 | Chelsea | 19:45 |
| Rosenborg | 0-2 | Schalke | 19:45 |
| Lazio | 2-2 | Real Madrid | 19:45 |
| Bremen | 1-3 | Olympiakos | 19:45 |
| Celtic | 2-1 | Milan | 19:45 |
| Benfica | 0-1 | Shakhtar | 19:45 |
| Tuesday 23 October 2007 | |||
| Stuttgart | 0-2 | Lyon | 19:45 |
| Rangers | 0-0 | Barcelona | 19:45 |
| Dynamo Kyiv | 2-4 | Manchester United | 19:45 |
| Roma | 1-2 | Sporting | 19:45 |
| CSKA Moscow | 1-2 | Inter | 18:30 |
| PSV | 0-0 | Fenerbahce | 19:45 |
| Sevilla | 2-1 | Steaua Bucharest | 19:45 |
| Arsenal | 7-0 | Slavia Prague | 19:45 |
| Wednesday 24 October 2007 | |||
| Besiktas | 2-1 | Liverpool | 19:45 |
| Marseille | 1-1 | Porto | 19:45 |
| Rosenborg | 2-0 | Valencia | 19:45 |
| Chelsea | 2-0 | Schalke | 19:45 |
| Bremen | 2-1 | Lazio | 19:45 |
| Real Madrid | 4-2 | Olympiakos | 19:45 |
| Benfica | 1-0 | Celtic | 19:45 |
| Milan | 4-1 | Shakhtar | 19:45 |
| Tuesday 6 November 2007 | |||
| Liverpool | 8-0 | Besiktas | 19:45 |
| Porto | 2-1 | Marseille | 19:45 |
| Valencia | 0-2 | Rosenborg | 19:45 |
| Schalke | 0-0 | Chelsea | 19:45 |
| Lazio | 2-1 | Bremen | 19:45 |
| Olympiakos | 0-0 | Real Madrid | 19:45 |
| Celtic | 1-0 | Benfica | 19:45 |
| Shakhtar | 0-3 | Milan | 19:45 |
| Wednesday 7 November 2007 | |||
| Lyon | 3-2 | Stuttgart | 19:45 |
| Barcelona | 2-0 | Rangers | 19:45 |
| Manchester United | 4-0 | Dynamo Kyiv | 19:45 |
| Sporting | 2-2 | Roma | 19:45 |
| Inter | 4-2 | CSKA Moscow | 19:45 |
| Fenerbahce | 2-0 | PSV | 19:45 |
| Steaua Bucharest | 0-2 | Sevilla | 19:45 |
| Slavia Prague | 0-0 | Arsenal | 19:45 |
| Tuesday 27 November 2007 | |||
| Stuttgart | 3-2 | Rangers | 19:45 |
| Lyon | 2-2 | Barcelona | 19:45 |
| Dynamo Kyiv | 1-4 | Roma | 19:45 |
| Manchester United | 2-1 | Sporting | 19:45 |
| CSKA Moscow | 0-1 | PSV | 18:30 |
| Inter | 3-0 | Fenerbahce | 19:45 |
| Sevilla | 3-1 | Arsenal | 19:45 |
| Steaua Bucharest | 1-1 | Slavia Prague | 19:45 |
| Wednesday 28 November 2007 | |||
| Besiktas | 2-1 | Marseille | 19:45 |
| Liverpool | 4-1 | Porto | 19:45 |
| Rosenborg | 0-4 | Chelsea | 19:45 |
| Valencia | 0-0 | Schalke | 19:45 |
| Bremen | 3-2 | Real Madrid | 19:45 |
| Lazio | 1-2 | Olympiakos | 19:45 |
| Benfica | 1-1 | Milan | 19:45 |
| Celtic | 2-1 | Shakhtar | 19:45 |
| Tuesday 4 December 2007 | |||
| Milan | 1-0 | Celtic | 19:45 |
| Shakhtar | 1-2 | Benfica | 19:45 |
| Tuesday 11 December 2007 | |||
| Marseille | 0-4 | Liverpool | 19:45 |
| Porto | 2-0 | Besiktas | 19:45 |
| Chelsea | 0-0 | Valencia | 19:45 |
| Schalke | 3-1 | Rosenborg | 19:45 |
| Real Madrid | 3-1 | Lazio | 19:45 |
| Olympiakos | 3-0 | Bremen | 19:45 |
| Wednesday 12 December 2007 | |||
| Rangers | 0-3 | Lyon | 19:45 |
| Barcelona | 3-1 | Stuttgart | 19:45 |
| Roma | 1-1 | Manchester United | 19:45 |
| Sporting | 3-0 | Dynamo Kyiv | 19:45 |
| PSV | 0-1 | Inter | 19:45 |
| Fenerbahce | 3-1 | CSKA Moscow | 19:45 |
| Arsenal | 2-1 | Steaua Bucharest | 19:45 |
| Slavia Prague | 0-3 | Sevilla | 19:45 |
| Tuesday 19 February 2008 | |||
| Schalke | 1-0 | Porto | 19:45 |
| Liverpool | 2-0 | Inter | 19:45 |
| Roma | 2-1 | Real Madrid | 19:45 |
| Olympiakos | 0-0 | Chelsea | 19:45 |
| Wednesday 20 February 2008 | |||
| Celtic | 2-3 | Barcelona | 19:45 |
| Lyon | 1-1 | Manchester United | 19:45 |
| Arsenal | 0-0 | Milan | 19:45 |
| Fenerbahce | 3-2 | Sevilla | 19:45 |
| Tuesday 4 March 2008 | |||
| Sevilla | 3-2 * | Fenerbahce | 19:45 |
| Manchester United | 1-0 | Lyon | 19:45 |
| Milan | 0-2 | Arsenal | 19:45 |
| Barcelona | 1-0 | Celtic | 19:45 |
| Wednesday 5 March 2008 | |||
| Chelsea | 3-0 | Olympiakos | 19:45 |
| Porto | 1-0 * | Schalke | 19:45 |
| Real Madrid | 1-2 | Roma | 19:45 |
| Tuesday 11 March 2008 | |||
| Inter | 1-0 | Liverpool | 19:45 |
| Tuesday 1 April 2008 | |||
| Roma | 0-2 | Manchester United | 19:45 |
| Schalke | 0-1 | Barcelona | 19:45 |
| Wednesday 2 April 2008 | |||
| Arsenal | 1-1 | Liverpool | 19:45 |
| Fenerbahce | 2-1 | Chelsea | 19:45 |
| Tuesday 8 April 2008 | |||
| Chelsea | 2-0 | Fenerbahce | 19:45 |
| Liverpool | 4-2 | Arsenal | 19:45 |
| Wednesday 9 April 2008 | |||
| Barcelona | 1-0 | Schalke | 19:45 |
| Manchester United | 1-0 | Roma | 19:45 |
| Tuesday 22 April 2008 | |||
| Liverpool | 1-1 | Chelsea | 19:45 |
| Wednesday 23 April 2008 | |||
| Barcelona | 0-0 | Manchester United | 19:45 |
| Tuesday 29 April 2008 | |||
| Manchester United | 1-0 | Barcelona | 19:45 |
| Wednesday 30 April 2008 | |||
| Chelsea | 3-2 | Liverpool | 19:45 |
| Wednesday 21 May 2008 | |||
| Chelsea | 1-1 * | Manchester United | 19:45 |
| * = win on penalties | |||